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How to install BioEdit on a Mac running Mac OS X

August 5, 2011

BioEdit is a very popular sequence alignment editor.  It was written by Tom Hall and it was made only for Windows.  This tutorial will show you how to install BioEdit on a Mac without the use of Parallels Desktop or other virtual desktop software running Windows in the background.

You’ll first need to install Wine.

To install Wine on your Mac, you’ll need an Intel Mac and should follow David Baumgold’s guide on how to install Wine on Mac OS X (check the comments below.  Some users have had success while others had some problems).  Follow his guide until you finish Part 3 Install Wine using MacPorts.  Then return to this page.

Install BioEdit using Wine

To install a BioEdit program, first download the installer file.  (http://www.mbio.ncsu.edu/bioedit/bioedit.html).  It should end with .exe.  Save the BioEdit installer file in your user directory (it should show up on the Places in your Finder, below your Desktop icon, and shows up as a little house icon).

Open Terminal and run the installer through Wine by using this command:

$ wine setup.exe

XQuartz will open (if it isn’t already), and soon you will the installer. Click through it to install the program.

Install Winetricks

To make BioEdit work, you’ll have to do some additional installations.  In the Terminal window, type:

$ sudo port install winetricks
$ sh winetricks mdac27

The Terminal will open the webpage in your browser. Download the software from the website and put it in /Users/YOURNAME/Library/Caches/winetricks/mdac27

Then on the Terminal window type again:

$ sh winetricks mdac27

Run BioEdit

Now you are ready to launch BioEdit.  To run BioEdit, type in Terminal:

$ cd ~/.wine/drive_c/BioEdit
$ wine BioEdit.exe

Make an short cut for launching BioEdit (optional)

It would be nicer not having to go to the Terminal everytime you want to use BioEdit.  You can make a icon that you can put on your dock in order to launch BioEdit quickly.  Go to your Spotlight search at the top right corner and type “AppleScript Editor”.  Once the program opens, in the big blank space, copy and paste the following:

tell application "Terminal"
    do script "/opt/local/bin/wine ~/.wine/drive_c/BioEdit/BioEdit.exe"
end tell

Next, press the Compile button at the top of the window. The text should become colored. Try pressing the Run button to run your script and it should open BioEdit successfully.  Save your script.  You can give it whatever name you’d like, but be sure to select File Format: Application in the save options, and leave Startup Screen unchecked.  Open up the Finder, go to where you saved your script/app, and drag that file to your Dock. It should stay there, just like a real application.  Now you can click it to launch BioEdit quickly without having to type in the Terminal.

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69 Comments
  1. Guilherme Debortoli permalink

    Worked really well!! Thank you very much!
    Recomended!!

  2. Brad Redfearn permalink

    Thanks for sharing! Worked great for me.

  3. Ivo permalink

    Incredible! Easy to do. Thanks a lot!

  4. Nathan McNulty permalink

    What a relief to finally have access to BioEdit again. Thanks so much!

  5. Diana permalink

    I was really hoping I would get this to work, but I’m running Mac OS X 10.7 (Lion) and it doesn’t seem to work. I get hung up at step 2:install wine using MacPorts. I get the following warnings – any suggestions?
    Warning: The Command Line Tools for Xcode don’t appear to be installed; most ports will likely fail to build.
    Warning: See http://guide.macports.org/chunked/installing.xcode.html for more information.
    —> Computing dependencies for wineError: Unable to execute port: can’t read “build.cmd”: Failed to locate ‘make’ in path: ‘/opt/local/bin:/opt/local/sbin:/bin:/sbin:/usr/bin:/usr/sbin’ or at its MacPorts configuration time location, did you move it?
    To report a bug, see

    Thanks!
    Diana

    • phylogeneticgeek permalink

      Hi Diana

      I am not sure as I haven’t tried installing it on 10.7… Have you signed up for the free Apple developer account and installed Xcode, the Java development package and x11?

  6. Plinio Trabasso permalink

    Hi,

    I’ve got the same problem reported by Diana. During Step 2, I got the message below:

    Warning: The Command Line Tools for Xcode don’t appear to be installed; most ports will likely fail to build.
    Warning: See http://guide.macports.org/chunked/installing.xcode.html for more information.
    —> Computing dependencies for wineError: Unable to execute port: can’t read “build.cmd”: Failed to locate ‘make’ in path: ‘/opt/local/bin:/opt/local/sbin:/bin:/sbin:/usr/bin:/usr/sbin’ or at its MacPorts configuration time location, did you move it?
    To report a bug, see

    I’m using MacOS Lion (10.7), running appropriate versions (i.e, MacOS 10.7) of Apple Xcode, Java Development Package and MacPorts. Do you have any suggestion?

    Thanks

    Plinio

    • phylogeneticgeek permalink

      Hey Plinio,

      Thanks for reporting this. For the time being I do not know how to solve this problem. However, if you do manage to figure it out, please share your solution. I don’t have 10.7 on my computer so I am unable to play around with it. I know it’s a temporary fix, but I have changed the title of the article to say that it only works for 10.6 (which is what I have managed to get working for me).

    • Once Xcode was finished, you need install the command line tools: run Xcode and open the Preferences. Go to the Downloads tab, and install the Command Line Tools. You’re done!

  7. Daphne permalink

    I tried to install BioEdit for 10.5.8. when i enter – $ wine setup.exe command in the terminal (step 3) i get the following: command not found. what am I doing wrong? any suggestions?

    • phylogeneticgeek permalink

      Hi Daphne

      I’m sorry I am not too sure… Perhaps you were not in the correct directory? But it sounds that it does not know the wine command which it should if it was successfully installed.

  8. Juliet permalink

    Hi,
    Thanks for posting. I was able to complete every step except for the last one – when I try to open BioEdit, I can see the program begin to open for a second, and then it shuts down suddently, and there’s an error message from my Mac saying “The application X11 quit unexpectedly.”

    Any experience with this kind of error?

    Thanks so much!

    Juliet

    • phylogeneticgeek permalink

      Hi Juliet

      I have not experienced this kind of error. Maybe you could try to update x11 or reboot your machine.

    • Harald Lecz permalink

      Hi Juliet,
      had the same problems on 10.5.8: update your X11, that should work!

      Best

      Harald

  9. Juliet permalink

    I should mention that I’m using a Mac OS X 10.5.8. Thanks!! :)

  10. Hi there,

    I completed till part 4 without any problems but I am stuck in part 5 i.e. Run BioEdit section. When I typed cd ~/.wine/drive_c/BioEdit it says that “No such file or directory” I am wondering to where I should change my working directory. It didn’t find any BioEdit packages in my system …Actually, it’s in the downloaded folder the whole bioedit packages and I didn’t change the location of the downloaded packages. So, to where I should change my working directory to run the BioEdit?

    Many Thanks!
    Keshav

    • phylogeneticgeek permalink

      Hi there,
      Sorry for taking so long to answer back. Try moving the installer exe for Bioedit to your user directory (the place with the little home icon) and then install it using wine (see part 3). Once you’ve moved the installer file for BioEdit there, type wine install.exe (where “install.exe” is the installer file name for the BioEdit installer, I can’t remember what it is now).

  11. Areli permalink

    Awsome it works!

  12. Daniel permalink

    Work great so far! many many thanks.

  13. Jordan Fox permalink

    This is amazing! Thank you so much – a great help. I’m using Lion 10.7.4 and it works perfectly.

    • phylogeneticgeek permalink

      I’m glad it worked out for you. Thanks for reporting back that it can work on 10.7!

  14. Waqar Jadoon permalink

    How to install BioEdit on a Mac running Mac OS X 10.7.5

    I want to install BioEdit on my MacBook pro according to your above stated protocol but couldn’t install. I did it successfully up to Part 1 of above said manual and when started the Part 2 that is (Install Wine using MacPorts) but after this step the Terminal gives an error, so I dont know how to resolve this problem.
    I request you if some one can help me I will be highly obliged.

    Regards,

    Waqar

    • phylogeneticgeek permalink

      Sorry could you be more specific to the error. Were you able to successfully complete step 2 and install wine through macports at all? Was your error at step 3?

  15. hersheyfellow permalink

    Thank you phylogeneticgeek! It worked on my Macbook PRO OS X 10.8 Mountain Lion! I had to install X11. Had to fix other bugs, like the D-bus where it said “Dynamic session lookup supported but failed: launchd did not provide a socket path, verify that org.freedesktop.dbus-session.plist is loaded!” on Terminal. I found another site helpful along with this one! Thanks again! Other site that helped me: http://www.davidbaumgold.com/tutorials/wine-mac/

  16. Suzan permalink

    I also want to comment that I was able to install this on my OS X 10.8.2 (Mountain Lion). The link that hersheyfellow gave (http://www.davidbaumgold.com/tutorials/wine-mac/) works really well. But if you want to open BioEdit you should use step 5 of this page. It runs great!

  17. Asanka R. Bandara permalink

    Hi Phylogeneticgeek,
    I couldn’t find Java Development Package. I’m using OS X 10.8.2 Could you please help me to this
    Many Thanks,
    Asanka

  18. David permalink

    I can’t find the fold Users/YOURNAME/Library/Caches/winetricks/mdac27. Anyone can help me ? Just the last step!

  19. NIAZ MUHAMMAD permalink

    Bioedit doesn’t work work on MacBook Air :(

  20. Nathan McNulty permalink

    As others have reported, BioEdit runs just fine on Mountain Lion 10.8.2 if the steps above are followed carefully. Thanks also to hersheyfellow for helping me kill the annoying bug at startup (which didn’t seem to interfere with BioEdit running, but always ‘bugged’ me).

  21. Nathan McNulty permalink

    Seems that I spoke too soon, sort of — one of the features of BioEdit I value most highly (i.e., pairwise alignments while allowing ends to slide) appears to be broken now. Attempting such an alignment on 10.8.2 generates the following error, which I didn’t get before: “External exception EEFFACE.” A little Googling around suggests this may be the result of attempting to read/write beyond the bounds of a std::vector in C++ Builder. Runtime exceptions like this go far beyond my debugging abilities. Is anyone else with a 10.8.2 installation able to perform pairwise alignments while allowing ends to slide? I’ve never been able to find other software that allows me to do this, so I’m keen to get this working again.

  22. Nathan McNulty permalink

    Moderator, feel free to remove this comment and my previous one about the EEFFACE errors I’ve been getting. While the error is legitimate for the first sequences I tested, it seems to somehow be specific to sequences that I’ve imported. If I create two new sequences from scratch within BioEdit and attempt to align them, things work fine. I’m guessing there must be some pernicious formatting error with my inputs that was causing the problems — it probably has nothing to do with the installation per se.

  23. NIAZ MUHAMMAD permalink

    Last login: Fri Jan 11 12:20:41 on ttys000
    NIAZs-MacBook-Air:~ niaz$ sudo port install wine
    Error: Port wine not found
    NIAZs-MacBook-Air:~ niaz$

    I’m stuck here in Part 2 “installing wine using mac ports” it gives me this above command

  24. NIAZ permalink

    NIAZs-MacBook-Air:~ niaz$ sudo port install wine
    Error: Port wine not found
    NIAZs-MacBook-Air:~ niaz$

    When I enter command “sudo port install wine” it gives me error saying “Port wine not found”
    Can some one help me explain how to install wine. I’m stuck in this step

  25. Julie permalink

    Thank you very much for the help! I have one remaining “fixme”. BioEdit is running, but if I minimize it kind of disappears from the menu bar.

    fixme:ieframe:PersistStreamInit_Load (0x1ed640)->(0x1ecb90)

    Each time I minimize the numbers at the end change. And I can get BioEdit back and all functions seem to work. I was just wandering if this last little “glitch” can be solved.

    Thank you.

    Julie

  26. Julie permalink

    I apologize for double posting! The fixme:ieframe:PersistStreamInit_Load (0x1ed640)->(0x1ecb90) occurs when I open a file into BioEdit. I just watched to see exactly when it occurred. Are there more winetricks? I have OS 10.8.2.

  27. Beth permalink

    Hi,

    I’ve used this on a previous MAC but can’t seem to get it to function now (Mac 10.7). The command “sh winetricks mdac27″ comes back with “no such file or directory”. I think I have winetricks already installed so i tried just going ahead and go to “wine BioEdit.exe” we results in a new X-code window with an error “error creating object. Please verify that the microsoft data …. has been properly installed.” It appears that it’s trying to launch but can’t get that far.

    Any suggestions?

  28. omer permalink

    Hi, I have a iMac OS X 10.8.2
    I colud do up to part 3.
    I wrote ‘sudo xcodebuild -license’ and than read and wrote ‘agree’
    Terminal have responded ‘You can view the license agreements in Xcode’s About Box, or at /Applications/Xcode.app/Contents/Resources/English.lproj/License.rtf’

    I have closed and reopened terminal window

    and than I have entered command (sudo port install wine)
    terminal responded:
    Warning: /opt/local/etc/macports/variants.conf specifies invalid variant syntax ‘sudo’, ignored.
    Warning: /opt/local/etc/macports/variants.conf specifies invalid variant syntax ‘xcodebuild’, ignored.
    Warning: /opt/local/etc/macports/variants.conf specifies invalid variant syntax ‘if’, ignored.
    Warning: /opt/local/etc/macports/variants.conf specifies invalid variant syntax ‘[‘, ignored.
    Warning: /opt/local/etc/macports/variants.conf specifies invalid variant syntax ‘`sysctl’, ignored.
    Warning: /opt/local/etc/macports/variants.conf specifies invalid variant syntax ‘hw.cpu64bit_capable`’, ignored.
    Warning: /opt/local/etc/macports/variants.conf specifies invalid variant syntax ‘1’, ignored.
    Warning: /opt/local/etc/macports/variants.conf specifies invalid variant syntax ‘]’, ignored.
    Warning: /opt/local/etc/macports/variants.conf specifies invalid variant syntax ‘;’, ignored.
    Warning: /opt/local/etc/macports/variants.conf specifies invalid variant syntax ‘then’, ignored.
    Warning: /opt/local/etc/macports/variants.conf specifies invalid variant syntax ‘echo’, ignored.
    Warning: /opt/local/etc/macports/variants.conf specifies invalid variant syntax ‘”+universal”‘, ignored.
    Warning: /opt/local/etc/macports/variants.conf specifies invalid variant syntax ‘|’, ignored.
    Warning: /opt/local/etc/macports/variants.conf specifies invalid variant syntax ‘sudo’, ignored.
    Warning: /opt/local/etc/macports/variants.conf specifies invalid variant syntax ‘tee’, ignored.
    Warning: /opt/local/etc/macports/variants.conf specifies invalid variant syntax ‘/opt/local/etc/macports/variants.conf;’, ignored.
    Warning: /opt/local/etc/macports/variants.conf specifies invalid variant syntax ‘else’, ignored.
    Warning: /opt/local/etc/macports/variants.conf specifies invalid variant syntax ‘echo’, ignored.
    Warning: /opt/local/etc/macports/variants.conf specifies invalid variant syntax ‘”not’, ignored.
    Warning: /opt/local/etc/macports/variants.conf specifies invalid variant syntax ’64bit’, ignored.
    Warning: /opt/local/etc/macports/variants.conf specifies invalid variant syntax ‘capable”;’, ignored.
    Warning: /opt/local/etc/macports/variants.conf specifies invalid variant syntax ‘fi’, ignored.
    Error: Port wine not found

    I did not understand
    help me?

  29. In J. Kim permalink

    Hi I am stuck on here.

    anybody can help me? I am using mountain lion.

    Thanks.

    MacBook-Pro:~ apple$ sh winetricks mdac27
    Executing w_do_call mdac27
    Executing load_mdac27
    Using native,builtin override for following DLLs: odbc32 odbccp32 oledb32
    Executing winetricks_early_wine regedit C:\windows\Temp\_mdac27\override-dll.reg
    Setting Windows version to nt40
    Executing winetricks_early_wine regedit C:\windows\Temp\_mdac27\set-winver.reg
    Executing wine /Users/apple/Library/Caches/winetricks/mdac27/mdac_typ.exe
    Application tried to create a window, but no driver could be loaded.
    Make sure that your X server is running and that $DISPLAY is set correctly.
    err:systray:initialize_systray Could not create tray window
    Application tried to create a window, but no driver could be loaded.
    Make sure that your X server is running and that $DISPLAY is set correctly.
    ——————————————————
    Note: command ‘wine /Users/apple/Library/Caches/winetricks/mdac27/mdac_typ.exe’ returned status 43. Aborting.

    • In J. Kim permalink

      I solved the problem by myself.

      After installing the XQuartz manually, every steps works fine.

      Thanks

  30. I cannot thank you enough for this, I love BioEdit and I’m happy to have it back in my life! Perfect instructions, it all went smoothly.

  31. Alexandre permalink

    Hi everyone,

    during the step 4 I’ve had the following error message from my terminal:

    Dynamic session lookup supported but failed: launchd did not provide a socket path, verify that org.freedesktop.dbus-session.plist is loaded!
    wine: cannot find L”C:\\windows\\system32\\setup.exe”

    Any guess?

    Thanks!

  32. Just wanted to say thank you & this worked.

  33. Dainiz permalink

    Hello!, after installing wine I came back to these instructions but when I called the installer trough wine this appeared in the console:

    MacBook-Pro-de-Dainiz:~ Dainiz$ wine setup.exe
    Fontconfig warning: ignoring UTF-8: not a valid region tag
    Application tried to create a window, but no driver could be loaded.
    Make sure that your X server is running and that $DISPLAY is set correctly.
    err:systray:initialize_systray Could not create tray window
    Application tried to create a window, but no driver could be loaded.
    Make sure that your X server is running and that $DISPLAY is set correctly.

    Could you please help me?
    Thanks a lot.
    Dainiz Hernández

  34. I get to the part where I should run BioEdit ($ wine BioEdit.exe) and this comes up via XQuartz Terminal:
    missing dependency
    this product requires Microsoft Internet Explorer 4.01 SP2 or greater. Please exit set up and install the latest Microsoft Internet Explorer.

    Any ideas?

    Appreciate any guidance :)

    • I figured out my own issue…..when I first installed BioEdit…and the last screen during install came up…where it asks if i want to launch BioEdit (check in the box) or not (unchecking the box)…i unchecked it and closed the installer window.
      THIS WAS THE PROBLEM!!!
      So…..:)…..What I did was retype the command:
      $ wine setup.exe

      causing BioEdit to install again. BUT this time i left the box checked (launch program) and followed with the steps that follow as desribed above. And Voila! ALL GOOD ;)

  35. Ivan permalink

    Hi, i have a Macbook Pro OS X 10.8.4
    I did all the steps well until i execute the comand “wine setup.exe” the installation window appears but when i did click on continue disappears and the Terminal box shows “fixme:storage:create_storagefile Storage share mode not implemented.”

    Please help me

    • Libby permalink

      So after a few days of errors and google, I have managed to successfully complete the install. First, the homebrew installation of Wine does not work, others have had the same problem with being stuck in the installer. Uninstall of wine was partially successful [the .wine directory remained and needed to be removed manually], the uninstall of homebrew had some scary comments that the provided script could damage the system. Instead I removed everything from /usr/local that homebrew had installed there. I then reinstalled wine via macports [the alternate page on the site with the homebrew instructions]. then installed winetricks. I then removed the .wine directory as it was returning an error when trying to install the mdac27. Installed mdac27 with winetricks. The ran the setup.exe for BioEdit. I found I needed to do the mdac27 installation first to get the installer to run. Finally I could run BioEdit. I did get a Dynamic session lookup error saying “launchd did not provide a socket path, verify that org.freedesktop.dbus-session.plist is loaded!” which didn’t seem to affect BioEdit loading, but I corrected it as well. Hope it works well now. So far I have been able to open old alignments and manipulate as previously.

  36. Libby permalink

    I am having the same issue as Ivan, also Macbook Pro OS X 10.8.4. Installed Wine via Homebrew as per the recommendations on the linked page, and installed winetricks mdac27 using the brew command instead of port. When executing wine setup.exe from the home directory the first few windows appear [initializing installer, etc]. Then the first msi window [the blue and white one] appears and upon selecting next the system stalls. the same fixme: error as above appears often before clicking next. Running WINEDEBUG shows where it stalls and it seems hung up on drawing the next window which would have the license information. Much googling gave no results except those that said a fixme shouldn’t be a catastrophic error.

    Any help would be appreciated.

  37. phylogeneticgeek permalink

    Thank you everyone for coming back to comment whether you were successful or you had problems but eventually figured out the solution.

    This is what science/life is all about right? Share what we know so it may help someone else. This is exactly why I started this post in the first place almost 3 years ago.

    Unfortunately I have been so incredibly busy with my doctoral studies that I no longer have the time to properly manage this page at a satisfactory level. Hopefully new users will read what you’ve all contributed in the comments section if they are running into problems.

    Again, thank you so much for your contributions.

  38. Sam permalink

    I had success running BioEdit on Mac OS X 10.8.4 by installing it using WineBottler. I remember I had to use the Winetrick for Microsoft Data Access Components 2.8 sp1 (mdac28) to make it run. But it installs very easily and can be packaged as its own Mac OS X application using WineBottler.

    This also worked really well with MEGA 5.2. In fact, using the MEGA app created through WineBottler, it runs better than the Mac version from the official website and has a smaller storage footprint.

  39. Ivan permalink

    Sam could you please help us giving an instructions list to do it?

  40. phylogeneticgeek permalink

    I tried what Sam suggested and here’s some very rough step by step instructions.

    1. Download WineBottler here http://winebottler.kronenberg.org/ . Also make sure you have XQuartz installed. http://xquartz.macosforge.org/landing/
    2. Open the WineBottlerCombo_1.4.1.6.dmg file and drag Wine and WineBottler apps to your Applications folder.
    3. Open WineBottler app
    4. Click on the Advanced Tab.
    5. Under “Program to Install”, click “Select file…” and then pick the setup.exe for BioEdit. Go to the BioEdit site if you don’t have it http://www.mbio.ncsu.edu/bioedit/bioedit.html. Leave the button on “This is an installer, execute it.”
    6. Where it says “Winetricks”, scroll down until you see “mdac28″ and click on the box to checkmark it.
    7. Where it says “Bundle”, click to check the box for “include wine binaries”
    7. On the bottom of the page, click on Install.
    8. Some windows will pop up, just click to accept licenses/etc just as you would install these programs under Windows.
    9. Once it’s finished, it will create the .app. I called it BioEdit.app.
    10. Click BioEdit.app to run it. That seemed to have worked for me.

  41. Asanka R. Bandara permalink

    I canot install winetricks. Once “sudo port install winetricks” command run following massage was displayed. Help
    Admins-MacBook-Pro:~ admin$ wine setup.exe
    err:winediag:SECUR32_initNTLMSP ntlm_auth was not found or is outdated. Make sure that ntlm_auth >= 3.0.25 is in your path. Usually, you can find it in the winbind package of your distribution.
    fixme:iphlpapi:NotifyAddrChange (Handle 0x10ef550, overlapped 0x10ef55c): stub
    wine: configuration in ‘/Users/admin/.wine’ has been updated.
    fixme:storage:create_storagefile Storage share mode not implemented.
    Admins-MacBook-Pro:~ admin$ sudo port install winetricks
    Password:
    Warning: port definitions are more than two weeks old, consider using selfupdate
    —> Extracting zlib
    Error: org.macports.extract for port zlib returned: command execution failed
    Please see the log file for port zlib for details:
    /opt/local/var/macports/logs/_opt_local_var_macports_sources_rsync.macports.org_release_tarballs_ports_archivers_zlib/zlib/main.log
    Error: Problem while installing zlib
    Error: Unable to execute port: upgrade openssl failed
    Admins-MacBook-Pro:~ admin$

  42. Santiago permalink

    Hi all,
    installing winestricks is taking to long… more than 2 hours and still running…. is that fine?

  43. Santiago permalink

    Hi David, I have the same problem… did you fix it?

  44. Santiago permalink

    Awesome!! thank you!

  45. Sam permalink

    Sorry I didn’t get back to you guys – the step-by-step instructions that phylogeneticgeek wrote are what I did as well :)

  46. Thank you very much!!!..I successfully installed BioEdit following your tutorial, although having lots of error and trial. I am new to Mac, so had lots of problem and would say that its not easy to install. But few things to add that:
    1. Install Wine using MacPorts, another alternative (as from Homebrew it took hardly 10 minutes to install and was not complete).
    2. I install Winetricks before BioEdit.
    3. After installing Winetricks at command (sh winetricks mdac27), I could not find Library in my User directory, then I learned it is hidden by default in Mac OS x10.8 or newer version. Which I Open by giving command in terminal (chflags nohidden ~/Library/), it will permanently reveal your Library in user directory, but if you want to hide it again for safety purpose, give the command (chflags hidden ~/Library/).
    4. After that, as written Xquartz will open, I don’t why, it did not happen in my case. But I proceed further.
    5. While installing BioEdit, when I gave command $ wine setup.exe, it showed some error (wine: cannot find L”C:\\windows\\system32\\install.exe”). Instead of pasting whole folder there, I copied all files of BioEdit zip folder one by one in user directory and tried again, which worked.

    Then I followed the instruction and it worked without any error. I am highly Thankful to all of you guys, your feedback really helped me a lot to bring BioEdit in my life again.

    It would be helpful if someone shares about how to install MEGA programme on Mac.

    Just to add information that I installed BioEdit 5.09 version on MacBook Pro OS x 10.8.5.

  47. Whenever I open BioEdit, terminal also open and says:

    /opt/local/bin/wine ~/.wine/drive_c/BioEdit/BioEdit.exe
    Farzanas-MacBook-Pro:~ fsabir$ /opt/local/bin/wine ~/.wine/drive_c/BioEdit/BioEdit.exe
    Dynamic session lookup supported but failed: launchd did not provide a socket path, verify that org.freedesktop.dbus-session.plist is loaded!
    err:ntdll:RtlpWaitForCriticalSection section 0x7bc8fc74 “loader.c: loader_section” wait timed out in thread 001c, blocked by 001d, retrying (60 sec)

    and then it opens the BioEdit window. I was wondering if it is the normal way of opening BioEdit or am I missing something, although after opening BioEdit works perfect.

  48. OK….now here I have problem…I can not work in two windows of BioEdit. and most importantly I can not do clustal alignment..it says that I have to install Dos box…any suggestions please!!!!

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  52. Meg permalink

    Can someone help me? I’m a computer programming N00b and I’ve managed to successfully follow the steps up until Wine Tricks. I type in the commands as stated “sudo port install winetricks” but after entering my password I am told “sudo: port: command not found”

    Any suggestions?

    I also get this message when I run brew doctor: (not sure if it means anything)

    Warning: Homebrew’s sbin was not found in your PATH but you have installed
    formulae that put executables in /usr/local/sbin.
    Consider setting the PATH for example like so
    echo export PATH=’/usr/local/sbin:$PATH’ >> ~/.bash_profile

    THANKS!!!!

  53. reynaldo permalink

    hello, my name is Reynaldo, I am trying to install Bioedit in mac OS X 10.9.4, but I have a hurt time with this. However I get all the step 1, 2 and 3 in installling wine on mac and then I follow thw step on http://phylogeneticgeek.wordpress.com/2011/08/05/how-to-install-bioedit-on-a-mac/ I get the instal bioedit using wine but when I try to install winetrick, I have this problem:

    MacBook-Pro-de-MACARENA:BioEdit macarenadelpilarbarrajimenez$ wine setup.exe
    fixme:storage:create_storagefile Storage share mode not implemented.
    fixme:ntdll:find_reg_tz_info Can’t find matching timezone information in the registry for bias 240, std (d/m/y): 27/04/2014, dlt (d/m/y): 7/09/2014
    MacBook-Pro-de-MACARENA:BioEdit macarenadelpilarbarrajimenez$ sudo port install winetricks
    Password:
    sudo: port: command not found

    there are someone who guideme from this step?
    Thanks

    • Has Miseq permalink

      Wonderful! Steps were easy to follow. Thank you very much :)

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